EnglishAutophagy Center

Outline

The Osaka University Graduate School of Medicine's Project for the Creation of New Research Fields aims to promote innovative research that would be difficult to achieve in a single department through close collaboration between basic and clinical research.

As part of this project, we will build on our accumulated autophagy research to elucidate the regulatory mechanisms of intracellular membrane dynamics at the molecular level and clarify how their disruption affects the onset and progression of a wide range of diseases, including kidney disease, lifestyle-related diseases, neurodegenerative diseases, and liver diseases. In particular, we will focus on the autophagy regulators Rubicon and TFEB to elucidate their disease-specific roles and regulatory mechanisms, and promote the development and clinical application of autophagy drug discovery and autophagy monitoring methods based on these findings. Based on the previous results of autophagy research conducted at various departments of Osaka University, the ultimate goal of the project is to realize world-leading clinical applications of autophagy research through close collaboration between basic researchers and clinical researchers in various fields, and to contribute to the extension of healthy life expectancy.